Role of IL-1β, TNF-α, IL-10, IL-17, and IL-4 gene polymorphisms in the pathogenesis of chronic rhinosinusitis with nasal polyps

Background: chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease, those mechanisms are not fully understood. A significant role of cytokines, e.g., interleukin (IL)-1β, tumor necrosis factor (TNF) α, IL-10, IL-17А, IL-4, and their genes, in the pathogenesis predisposition to CRSwNP treatment efficacy established. Aim: investigate IL-1β (Т-31С), TNF-α (G-308A), IL-10 (G-1082A), IL-17(G-197A), IL-4 (С-589Т) gene polymorphisms pathogenesis. Patients Methods: this open-label, prospective, randomized study enrolled 100 patients CRSwNP. The control group included 72 healthy volunteers. DNA was isolated from whole venous blood. IL-17 (G-197A), were assessed by real-time polymerase chain reaction (PCR). Results: analysis polymorphism has demonstrated that 589С/С genotype more common compared controls (р=0.021, odds ratio/OR=1.248 [0.449–3.465]). (G-1082A) 1082А/A (p=0.043, OR=1.027 [0.374–2.830]). (G-197A) 197A/А than (p=0.046, OR=7.250 [0.863–2.532]). (G-308A) 308 G/G (p=0.045, OR=1.789 [0.892–4.776]). Conclusion: most relevant predictors increased risk gene, gene. essential cytokine polymorphisms, i.e., IL- 1β (С-589Т), allows assessing genetic This technique an important tool for predicting efficacy. KEYWORDS: polyps, genotype, polymorphism, pathogenic mechanisms. FOR CITATION: Baranova N.I., Molotilov B.A., Ashchina L.A., Shkurova N.A. Role IL-1β, TNF-α, IL-17, polyps. Russian Medical Inquiry. 2022;6(2):57–61 (in Russ.). DOI: 10.32364/2587-6821-2022-6-2-57-61.